Structural and Functional Left Ventricular Remodelling in Patients With Obstructive Sleep Apnea

Associação Fundo de Incentivo à Pesquisa450 enrolled

Overview

The purpose of this study is to determine whether patients with obstructive sleep apnea have any changes in left ventricular function and structure after 06 months of continuous positive airway pressure treatment.

Several studies have been suggesting that Obstructive Sleep Apnea contributes to deterioration of left ventricular diastolic function. It may be associated to increased risk of cardiovascular events. We hypothesized that morphological and functional left ventricular changes might be reverted after treatment with Continuous positive airway pressure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

450

Conditions

Obstructive Sleep Apnea

Interventions

CPAP (continuous positive airway pressure)DEVICE

Patients treated by CPAP for 06 months

Eligibility

Sex: ALLMin age: 35 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Apnea-hypopnea index higher than 5 events per hour Exclusion Criteria: * Body mass index higher than 40 kg/m2

Locations (1)

Instituto do Sono/AFIP

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Improvement of left ventricular diastolic echo variable

Time frame: 06 months

Data from ClinicalTrials.gov

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