Study hypothesis: The recurrence rate of HCC patients after radical resection is about 60-70%. This study is based on the hypothesis that CIK treatment could decrease the recurrence rate by 15% to 20%. Abstract: This is a randomized controlled study. About 200 patients with hepatocellular carcinoma who underwent radical resection will be included. The patients will be randomized to group A (receive CIK treatment) or group B (just regularly follow up) without any anti-cancer treatment after resection of HCC, and the randomize ratio will be 1:1. Study treatment: Patients in group A will receive 4 cycles of CIK treatments within 3 months after their liver resection. Patients in group B will have no anti-cancer therapy. Anti-virus and other supportive therapies are available in both groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
200
cytokine-induced killer cell treatment every two weeks, for 4 cycles
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
Time to recurrence (TTR)
Time frame: month
Overall survival (OS)
Time frame: month
Progression Free Survival (PFS)
Time frame: month
Laboratory findings
Time frame: every 3 months
AEs and SAEs
Time frame: monthly
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