Conditioning Regimen Before Infusion of Allogeneic Hematopoietic Stem Cells

Cooperative Study Group A for Hematology52 enrolled

Overview

Unrelated Donor Hematopoietic Stem Cell Transplantation After Nonmyeloablative Conditioning for Younger Patients with Hematologic Malignancies.

Primary end points are treatment-related mortality and engraftment. Secondary end points are regimen-related toxicities, graft-versus-host-disease, relapse, and overall survival.

Study Type

OBSERVATIONAL

Enrollment

Conditions

HEMATOLOGIC MALIGNANCIES

Eligibility

Sex: ALLMin age: 15 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: -Patients should have an unrelated donor who is matched for HLA-A and -B by serology and for -DRB1 by molecular typing. Exclusion Criteria: * Patients should not have major illness or organ failure * Patients must not have a psychiatric disorder or mental deficiency severe as to make compliance with the treatment unlike, and making informed consent impossible. * Patients must not be pregnant or lactating.

Locations (1)

Asan Medical Center

Seoul, South Korea

Outcomes

Primary Outcomes

treatment-related mortality and engraftment

Time frame: all cause mortality

Secondary Outcomes

regimen-related toxicities, graft-versus-host-disease, relapse, and overall survival.

Time frame: Time point(s) at which outcome measure is assessed.

Data from ClinicalTrials.gov

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