Cholesterol-lowering drugs called statins improve the functioning of the endothelium, and help prevent heart disease. The investigators are testing whether statins improve endothelial function more in the arteries that have worse endothelium to begin with. One of the functions of the endothelium is to help control how blood vessels dilate (expand) or contract (narrow) in different situations. This affects how blood flows through those vessels. Magnetic resonance imaging (MRI) can be used to evaluate endothelial function in the arms and legs noninvasively.
Correct
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
16
80 mg everyday (QD) for 3 weeks
Harry SIlber, MD
Baltimore, Maryland, United States
Mean Change in Low Density Lipoprotein (LDL)
Serum LDL, mg/dL (baseline LDL-follow-up LDL)
Time frame: Change from baseline to follow-up, up to 5 weeks
Change in Endothelial Function as Measured on MRI in the Arms
Time frame: chance from baseline to end of study, up to 5 weeks
Change in Endothelial Function as Measured on MRI in the Legs
Time frame: chance from baseline to end of study, up to 5 weeks
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