In this randomized study the investigators wish to explore the role of pre-procedural statin therapy for the prevention of contrast induced nephropathy in patients with moderate-to-severe renal dysfunction, submitted to elective coronary or angioplasty.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
304
80 mg die
Contrast-induced nephropathy was defined as an absolute increase of at least 0.5 mg/dl from the baseline value in serum creatinine concentration within the first 24 hours after contrast exposure and peaking up to 5 days afterwards
Time frame: within 5 days after contrast exposure
Relative increase ≥ 25% over baseline serum creatinine within 5 days after contrast agent administration
Time frame: within 5 days after contrast agent administration
Adverse clinical events within 1 month, including in-hospital death and need for dialysis or hemofiltration
Time frame: 1 month
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