Open Label Study of Ceftobiprole to Evaluate Pharmacokinetics in Adults Hospitalized in the ICU

Inclusion Criteria: * Informed Consent * Between 18 and 75 years of age inclusive * BMI 18 - 35 inclusive * Albumin \< 3.3 g/dL or clinical evidence of edema * Negative Pregnancy test * Expected survival of at least 7 days Exclusion Criteria: * Known drug allergy (including penicillin, cephalosporin, carbapenems, or other beta-lactams) * Renal impairment (CrCl \< 50 mL/min) or dialysis * History of seizures * ALT or AST \> 5 times upper normal limit * Sustained shock, unresponsive to sympathomimetics * Conditions that may have jeopardized adherence to the protocol (NYHA Class 4 cardiac disease, \>15% total body burn or significant third degree burn)