The main objective is to research for genetic factors involved in the extreme modifications of the QT interval of the electrocardiogram in answer to a pharmacological stimulation (sotalol) and physiological stimulation in the apparently normal general population. The phenotypic characterization, based on the ventricular repolarisation dynamics will be used aiming at term of the predictive genetic factors of the acquired long QT syndrome
Study of 1000 apparently healthy subjects which will receive an unique dose of Sotalol and will have an effort test on ergonomic bicycle, an auditive stimulation and a taking of DNA.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
997
healthy subjects will receive an unique dose of Sotalol and will have an effort test on ergonomic bicycle, an auditive stimulation and a taking of DNA
Centre d'investigation clinique; Hôpital Saint Antoine
Paris, France
The elongation of the corrected interval QT duration 3 hours after the unique oral taking of an 80 mg dose of Sotalol.
Time frame: 3 hours after the taking of Sotalol
Constitute a biological base and a phenotypic base of resources which will allow to define answer phenotypes to the implemented dynamic tests
Time frame: At the inclusion visit
Look for associations between these phenotypes of electrocardiographically answer and mutations or polymorphisms.
Time frame: At the inclusion visit
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