Improving Glycogen Liver Content Will Improve Post-operative Liver Function in Patients Undergoing Major Liver Resections

McGill University Health Centre/Research Institute of the McGill University Health Centre60 enrolled

Overview

We would like to study the effect of preserving liver glycogen storage by using intravenous dextrose infusion on postoperative liver function and complications after major liver resections.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Liver Function

Interventions

dextrose 10% (D10W ®) infusionDRUG

Started at 8pm the day before surgery until the procedure begins

hyperinsulinemic normoglycemic clampDRUG

Started as the procedure begins, decreased at the end of the procedure and continued until 16 hours postoperatively

high calorie diet 35 kcal/kgDIETARY_SUPPLEMENT

High Calorie meals start the day before the surgery and are given 5 hours apart. The last meal is given at 7 pm the day before surgery

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * planned to undergo a major liver resection at McGill University Health Center (MUHC) Exclusion Criteria: * patients known with chronic viral liver disease * uncontrolled or type one diabetes mellitus (DM) * patients on oral beta-blocker agents * patients with unresectable disease determined intra-operatively * patients unable to give consent for the study.

Locations (1)

Royal Victoria Hospital

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Postoperative liver function test

Time frame: Postoperative

Secondary Outcomes

Liver and muscle glycogen, TG, and protein content at beginning and end of the procedure.

Time frame: Begining + end of the procedure

Incidence of complications

Time frame: Postoperative

Data from ClinicalTrials.gov

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