Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue

German Institute of Human Nutrition17 enrolled

Overview

This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in subcutaneous adipose tissue.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Metabolic Syndrome Obesity Insulin Sensitivity

Interventions

Glucose dependent insulinotropic polypeptide (GIP)OTHER

GIP-Infusions for 4 h in a postprandial concentration

Eligibility

Sex: MALEMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI \> 28 * Healthy subjects * Normal glucose tolerance Exclusion Criteria: * Diabetes,IFG, IGT * Chronical-inflammatory diseases * Hb \< 12g/dl * Elevation in liver enzymes or creatinin concentrations * Great weight changes within last 12 months * Any cancer diagnosis in last 10 years

Outcomes

Primary Outcomes

Changes in gene expression of subcutaneous adipose tissue with microarray analysis

Time frame: 3 years

Secondary Outcomes

Analysis of inflammatory marker (blood levels and gene expression), Activity of 11beta HSD and 11-beta HSD mRNA in adipose tissue, etc.

Time frame: 3 years

Data from ClinicalTrials.gov

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