A Study Evaluating Systemic Exposure and Pharmacodynamics in Patients With Chronic Obstructive Pulmonary Disease

Inclusion Criteria: * Able to understand the requirements of the study and provide consent * Medical diagnosis of COPD * A current or prior history of at least 10-pack years of cigarette smoking * Female of child-bearing potential to use adequate birth control Exclusion Criteria: * Diagnosis of asthma * Other significant disease than COPD * Has donated a unit of blood within 30 days of study, or intends to donate * QTc greater than 0.460 seconds * Subjects who had radiation or chemotherapy in the previous 12 months * Subjects who had lung resection * History of illegal drug abuse or alcohol abuse within the past 5 years