Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure

Hospital Clinic of Barcelona128 enrolled

Overview

The purpose of the study is to determine the optimal method to withdraw non-invasive ventilation after an episode of hypercapnic respiratory failure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

128

Conditions

Hypercapnic Respiratory Failure

Interventions

Nocturnal non-invasive ventilationDEVICE

Prolongation of non-invasive ventilation during 3 nights.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Acute hypercapnic respiratory failure. * Use of NIV to treat respiratory failure. * Persistence of hypercapnia after discontinuation of NIV Exclusion Criteria: * Home NIV * Facial or cranial trauma or surgery, * Recent gastric or esophageal surgery, * Active upper gastrointestinal bleeding, * Excessive amount of respiratory secretions, * Tracheostomy * Lack of cooperation

Locations (3)

Hospital del Mar

Barcelona, Barcelona, Spain

Hospital de Sant Pau

Barcelona, Barcelona, Spain

Hospital Clinic

Barcelona, Barcelona, Spain

Outcomes

Primary Outcomes

New episode of hypercapnic respiratory failure after discontinuation of non-invasive ventilation

Time frame: At the end of enrollment time

Secondary Outcomes

Incidence of long term dependency on non-invasive ventilation

Time frame: At the end of enrollment time

Hospital and 6-month survival

Time frame: At the end of enrollment time

Data from ClinicalTrials.gov

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