Efficacy of Candesartan on Reducing Blood Pressure in Insulin-Resistant, Obese Patients With Hypertension.

Inclusion Criteria: * Has an Abdominal obesity with a waist circumference greater than 102 cm (men) and greater than 88 cm (women). * Has a body mass index greater than 30 kg/m\^2. * Has hypertension not adequately controlled (seated diastolic blood pressure greater than 95 mmHg and less than or equal to 110 mmHg as median value of three readings) by monotherapy with either beta-blocker or calcium channel blocker. * Has a Homeostasis Model Assessment Insulin Resistance index greater than 3.99. * Has hyperlipidemia with fasting levels for total cholesterol greater than 250 mg/dL (6.45 mmol/L) or low-density lipoprotein cholesterol greater than 160 mg/dL (4.13 mmol/L) or triglycerides greater than 250 mg/dL (2.82 mmol/L). Exclusion Criteria: * Existing Hydrochlorothiazide therapy at start of study. * Diabetes mellitus type 1 or 2 \[known or newly detected (Screening: fasting plasma glucose greater than 7.0 mmol/L)\]. * Chronic renal impairment or S-creatinine greater than or equal to 1.8 mg/dL. * Presence of single kidney or state after kidney transplantation or known bilateral renal artery stenosis or interventional treatment for renal artery stenosis in the last year. * Hyperkalemia (potassium greater than 5.5 mmol/L). * Known electrolyte imbalance, e.g. hypocalcaemia or hypokalemia resistant to treatment. * Nephrotic syndrome. * Thyroid dysfunction. * Primary or secondary hyperaldosteronism. * Cushing syndrome. * Known or suspected familial hypercholesterolemia. * Severe hepatic impairment (cholestasis (bilirubin greater than 2.0 mg/dL) or alanine aminotransferase and/or aspartate aminotransferase greater than 3 times the upper limit of normal and/or γ-glutamyl transpeptidase greater than 5 times the upper limit of normal). * History of chronic heart failure. * History of overt coronary heart disease. * History of silent myocardial infarction. * Hemodynamically relevant stenosis of the mitral and/or aortic valve. * History of stroke. * Stage 3 hypertension (systolic blood pressure greater than 180 mmHg or diastolic blood pressure greater than 110 mmHg). * Angiotensin converting enzyme inhibitor or angiotensin receptor blocker therapy in the previous 4 weeks. * Lipid-lowering therapy with cholesterol synthesis enzyme inhibitors or anticipated initiation of such a therapy. * History of autoimmune disease. * History of cancer in the last 5 years or wasting disease. * Intake of prohibited concomitant medication. * Has known hypersensitivity/allergy to the study drugs. * Has drug addiction and/or extensive use of alcohol. * Psychological and/or emotional problems which would render the informed consent invalid or limit the ability of the patient to comply with the study requirements. * Participation in a clinical investigation within 30 days prior to enrolment in this trial.