Donepezil Therapy and Changes of Symptoms and Glucose Metabolism in Patients With Dementia With Lewy Bodies (DLB)

Inclusion Criteria: DLB patients: * who fulfill the diagnostic criteria of DLB * 60 to 85 years old * right-handed * Clinical Dementia Rating (CDR) ≧ 0.5 * Mini Mental State Examination (MMSE) score from 10 to 26 Normal Controls: * who are independent * who have no subjective or objective cognitive impairment * 60 to 85 years old * right-handed * MMSE score over 24 Exclusion Criteria: DLB patients: * who have diabetes mellitus * who have pathological change on MRI other than brain atrophy * who have complication or history of dementia other than DLB, psychiatric disease, and physical disorder that affect brain function * who have severe complication of cardiovascular, hepatic, renal, or other diseases unable to secure the safety * who have severe digestive ulcus * who have severe bronchitic asthma or obstructive lung disease * who have no caregiver who knows patient's condition well Normal Controls: * who have diabetes mellitus * who have taken donepezil before * who have abnormal findings on MRI * who have complication or history of brain injury, psychiatric disease, and physical disorder that affect brain function