Compared to solid foods, the nutritional energy of drinks may bypass the appetite regulation leading to obesity development. Although drinks sweetened with aspartame are available the anticipated positive effect of these drinks on obesity development has not been convincing. However, the mechanisms linking drinks intake to obesity are yet to be clarified. The investigators aim is to investigate the long-term effects of intake of soft drinks, milk and water. The study is a parallel, intervention trial with 80 overweight, healthy volunteers. They will be randomly selected to drink one liter a day of one of the four drinks for six months. The objectives are changes in numerous circulating metabolic risk factors, changes in body weight, anthropometric data and fat distribution (measured by DEXA, MRI and MR-spectroscopy). The investigators expect to clarify the mechanisms linking drinking habits to obesity development and provide scientifically based nutritional guidelines.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
60
One litre a day for six months.
One litre a day for six months.
One litre a day for six months
One litre a day for six months.
Department of Internal Medicine/Endocrinology C, Aarhus University Hospital
Aarhus, Denmark
Body Weight (kg)
Time frame: Six months
MR spectroscopy
to assess liver fat and skeletal muscle fat
Time frame: Six months
Magnetic resonance imaging
to assess visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAAT)
Time frame: Six months
Dual-energy X-ray absorptiometry (DEXA) scan
to assess total fat mass (kg), lean body mass (kg), and bone mass (kg)
Time frame: Six months
Blood pressure
Systolic and diastolic blood pressure (mmHg)
Time frame: Six months
Circulating metabolic parameters: including serum urate
mmol/L
Time frame: Six months
fasting plasma glucose
mmol/L
Time frame: Six months
fasting serum insulin
pmol/L
Time frame: Six months
Oral Glucose Tolerance Test (OGTT)
AUC OGTT glucose and insulin, AUC HOMA-IR, and Matzuda index
Time frame: Six months
Fasting blood lipids
Total, LDL, and HDL cholesterol, and TAG (mmol/L)
Time frame: Six months
Fasting plasma FFA
mmol/L
Time frame: Six months
Fasting plasma PAI-1
ng/ml
Time frame: Six months
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