The overall aim of this research is to utilize wound derived inflammatory cells from diabetic versus non diabetic human chronic wounds to understand mechanisms that are responsible for disregulated inflammation in individuals with diabetes. Biology of normal (peripheral blood derived cells) versus wound derived cells will also be studied.
Specific aims: 1. To study biology of wound derived inflammatory cells and fluid from diabetic versus non diabetic wounds. 2. To characterize mechanisms that are responsible for dysregulated wound inflammatory cell function in individuals with diabetes. 3. To characterize differences in the biology of normal peripheral blood derived cells versus wound derived cells. The long-term goal of this study is to determine the molecular mechanisms underlying impaired wound healing in diabetics.
Study Type
OBSERVATIONAL
Enrollment
250
Blood will be drawn from subjects once and VAC sponge will be collected (which is normally discarded material per standard of care).
Comprehensive Wound Care Centers
Indianapolis, Indiana, United States
COMPLETEDComprehensive Wound Care Centers
Columbus, Ohio, United States
COMPLETEDUniversity of Pittsburgh - McKeesport
Pittsburgh, Pennsylvania, United States
RECRUITINGWound healing
Wound healing status
Time frame: Week 16
Infection status
CFU analysis of the wound fluid
Time frame: week 0
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University of Pittsburgh - Mercy
Pittsburgh, Pennsylvania, United States
RECRUITINGUniversity of Pittsburgh - Passavant
Pittsburgh, Pennsylvania, United States
RECRUITING