Efficacy of Bortezomib (Velcade(R)) in Patients With Advanced Waldenström Macroglobulinemia

Inclusion Criteria: ● Established diagnosis of Waldenström macroglobulinemia (the 2nd Workshop on Waldenstrom's macroglobulinemia) Patient must have had 1 (or 2) lines of chemotherapy containing alkylating agent and/or Fludarabine :and /or monoclonal antibody and must have : * Life expectancy \> 3 months * Age \> 18 years * ECOG performance status 0-1-2 * ANC \> 1 x 109/L * Creatinine clearance, calculated according to the formula of cockcroft and Gault \> 40 ml/min * Total bilirubin \< 2x ULN * ASAT, ALAT \< 2x ULN * A negative serum pregnancy test one week prior to treatment must be available both for pre-menopausal women and for women who are \< 2 years after the onset of menopause * Adequate contraceptive methods for males and pre-menopausal females for 6 months after treatment discontinuation. * Written informed consent * Platelets\> 100X 109 Exclusion Criteria: * Active secondary malignancy or chemotherapy/radiotherapy for any neoplastic disease other than Waldenström macroglobulinemia prior to the study * Medical condition requiring the long-term (estimated to be more than one month) use of oral corticosteroids * Patients with active bacterial, viral or fungal infection * Known infection with HIV, Hepatitis B (except post vaccinal profile) or C * Treatment with any, other investigational agent or participating in another trial within 30 days prior to entering this study * Lactation/pregnancy * Concurrent severe diseases which exclude the administration of therapy heart insufficiency NYHA grade III/IV, LEVF \< 50% and or RF \< 30%, myocardial infarction within the past 6 months prior to study * Severe pulmonary or heart problems (acute diffuse pulmonary and pericardial disease) * Severe chronic obstructive lung disease with hypoxemia * Severe diabetes mellitus * Hypertension difficult to control * Impaired renal function with creatinine clearance \< 40 ml/min according to the formula of Cockcroft and Gault * Cerebral dysfunction * Richter's syndrome * Neuropathy\> grade 1 * Positive Beta HCG * Severe Hepato cellular alteration