Open-Label Study to Evaluate the Immunogenicity of Bovine Collagen in ArteFill® by Skin Testing

Inclusion Criteria: * Subjects 18 years of age or older, male or female. * Subjects who are healthy and have normal skin on the volar surface of the forearm. * Subjects willing and able to comply with the requirements of the study. * Subjects willing and able to comply with the follow-up requirements. * Subjects willing and able to give written and verbal informed consent. Exclusion Criteria: * Subjects who are pregnant, nursing or intend to become pregnant. * Subjects who have had any form of collagen soft tissue treatment within the last 12 months. * Subjects who were or are currently being treated with any systemic immunosuppressive therapy including but not limited to chemotherapy agents or corticosteroids (including inhaled or insufflated) within the past 3 months. * Subjects who were or are currently being treated with any topical OTC drug or prescription therapy on their arms (below the elbow) within the past 3 months. * Subjects with a history indicative of abnormal immune function (e.g. auto- immune diseases, HIV, cancer, etc). * Subjects with known lidocaine hypersensitivity. * Subjects with known sensitivity to bovine collagen. * Subjects who have a history of dietary beef allergy, undergoing desensitization to beef products or planning to undergo desensitization within the study evaluation period. * Subjects with severe allergies manifested by a history of anaphylaxis. * Subject is currently enrolled in an investigational drug or device study. * Subject has received an investigational drug or an investigational device within 30 days prior to entering this study. * Subject has any skin pathology or condition that could interfere with the evaluation of the treatment areas.