Gene Therapy for Chronic Granulomatous Disease in Korea

Inclusion Criteria: * gp91 defective male patients with chronic granulomatous disease: confirmed by DHR * Weigh greater than or equal to 15 kg * History of severe infections: more than 2 times * Performance status: ECOG 0-2 * Patients must be free of significant functional deficits in major organs, but the following eligibility criteria may be modified in individual cases. * Heart: a shortening fraction \> 28%; QTc interval \< 0.44 * Liver: total bilirubin \< 2 × upper limit of normal; ALT \< 3 × upper limit of normal; AST \< 3 x upper limit of normal * Kidney: creatine \< 2 x normal * Blood: WBC \> 2,500/uL; platelet \> 100,000/uL; hematocrit \> 26% * Written informed consent obtained from patient (or guardian if patients age \< 19) Exclusion Criteria: * Presence of a HLA-matched sibling for stem cell donation * Evidence or history of malignant tumor * Presence of a severe infection * Presence of an active tuberculosis * Uncorrectable electrolyte, Ca, P * Unable to comply with the protocol or to cooperate fully with the Investigator or site personnel