This pilot study in our medical intensive care unit will evaluate the clinical and cost-effectiveness of an active surveillance program for methicillin-resistant Staphylococcus aureus (MRSA), compared to routine daily bathing with chlorhexidine gluconate (CHG)-impregnated cloths. Outcomes include rate of MRSA acquisition, and of other hospital-acquired infections (e.g., catheter-associated bloodstream infections).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
1,518
Patients will have nasal swabs performed upon ICU admission, upon discharge, and every 2 weeks while they remain in the ICU.
CHG-impregnated cloths (2%) will be used to bathe patients at least daily during the duration of their medical ICU stay. Surveillance cultures will be obtained on admission, discharge and every 2 weeks while in the ICU, but results will be blinded until conclusion of the study.
All patients will be placed in contact isolation until the results of their active surveillance cultures are negative; if positive, they will remain in isolation.
Christiana Hospital
Newark, Delaware, United States
Acquisition of Methicillin-resistant Staph Aureus (MRSA) Colonization or Infection
Number of patients who acquired MRSA by the time of ICU discharge (based on nasal swab or clinical culture).
Time frame: During ICU stay
Number of Participants With Central Line Associated Bloodstream Infection
Time frame: During ICU stay up to six months
Vancomycin Resistant Enterococcal Infection or Colonization
Time frame: During ICU stay
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