We do not know why diabetic patients cannot protect themselves against low blood sugar. Therefore, in this study, we will perform a comprehensive assessment of the body's response to low blood sugar by measuring changes in blood hormones, blood sugar production, and nerve signals.
Morning and afternoon hypoglycemic episodes of 70, 60, or 50 mg/dl produce increased blunting of subsequent counterregulation dependent upon the depth of preceding hypoglycemia. We wanted to test this hypothesis in healthy African American individuals to determine if there is a difference in their responses to varying depths of hypoglycemia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Enrollment
16
2 hour hyperinsulinemic euglycemic clamp (90 mg/dl)
2 hour hyperinsulinemic hypoglycemic clamp (70 mg/dl)
2 hour hyperinsulinemic hypoglycemic clamp (60 mg/dl)
catecholamines
Time frame: 2 hours
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2 hour hyperinsulinemic hypoglycemic clamp (50 mg/dl)