Improving Medication Compliance and Smoking Cessation Treatment Outcomes for African American Smokers

Inclusion Criteria: * African American * 18-75 years of age * Smoke more than 10 cigarettes per day * Have a functioning telephone number * Be interested in quitting smoking * Be willing to take 3 months of Chantix * Be willing to complete all study visits Exclusion Criteria: * Renal impairment * Evidence or history of clinically significant allergic reactions to Chantix * Cardiovascular event in the past month * History of alcohol or drug abuse/dependency in the past year * Major depressive disorder in the last year requiring treatment * History of panic disorder * Psychosis, bipolar or eating disorder * Use of antidepressants, antipsychotics, mood stabilizers/anticonvulsants or naltrexone * Use of tobacco products other than cigarettes * Use of nicotine replacement therapy, bupropion, clonidine or nortriptyline in the month prior to enrollment * Prior use of Chantix * Women who are pregnant, contemplating getting pregnant or breastfeeding * Plans to move from Kansas City during the 3 month treatment phase * Another household member enrolled in the study