The Role of Serum Anticholinergic Activity in ACVB Patients

Heidelberg University100 enrolled

Overview

Drugs with anticholinergic potential increase the risk of postoperative transient and persistent cognitive dysfunction especially in cardiac patients. The investigators main goal is to identify preoperative risk factors and to monitor postoperative patients' state in relation to SAA activity and bilateral BIS-EEG changes.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Acetylcholine Cognition BIS-EEG

Eligibility

Sex: ALLMin age: 55 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * written compliance to the study participation * a good knowledge in German speech * no red/ green blindness * no previous neurological and/or psychiatric illness * good ability to see and to hear * Mini-Mental-State-Examination (MMSE) better than 25 points Exclusion Criteria: * no written compliance to the study participation * bad knowledge in German speech * red/ green blindness * previous neurological and/or psychiatric illness * no ability to see and to hear * Mini-Mental-State-Examination (MMSE) lower than 25 points

Locations (1)

University of Heidelberg, Department of Anesthesiology, Heidelberg Medical School

Heidelberg, Baden-Wurttemberg, Germany

Outcomes

Primary Outcomes

Cognitive dysfunction measured by neurocognitive test battery

Time frame: 3 month postsurgery

Secondary Outcomes

SAA, BIS-EEG, descriptive patients' characteristics

Time frame: 24 h postsurgery

Data from ClinicalTrials.gov

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