Exploratory Study of Coronary Flow Reserve Measurements, a Non-Invasive Method for Coronary Function Measurements

Inclusion Criteria: * Males aged 45-75 years or females aged 60-75 years inclusive * Carotid and/or femoral atherosclerotic plaque, as assessed by carotid ultrasound examination within the last 5 years * Abnormal concentrations of lipids or lipoproteins in the blood * Provision of signed informed consent Exclusion Criteria: * Treatment with statins or other lipid-lowering drugs, e.g. fibrates, nicotinic acid, cholesterol absorption inhibitor, within the last 6 months before randomisation * Current smoking or snuff tobacco use * Major CV event (myocardial infarction (MI), stroke/ transitory ischemic attack (TIA), Acute Coronary Syndrome (ACS), revascularisation) within the last 6 months before randomisation * Symptomatic carotid stenosis, atrioventricular (AV) block, QT-prolongation, atrial fibrillation, sinus node disease (such as sick sinus syndrome or symptomatic bradycardia), chronic obstructive pulmonary disease (COPD) or asthma