Low Dose of Midazolam is Superior to Conventional Dose for Rapid Sequence Intubation in Emergency Department (ED)

Seoul National University Hospital

Overview

Midazolam has been used in rapid sequence intubation for a long time, and the recommended dose is 0.1mg/kg. In some studies, however, the reduced dose has been used with the concern of hemodynamic instability. We would like to investigate that the low dose midazolam could be used rather than the standard recommended dose, and also compare it to the etomidate, recently used sedatives, with respect to the side effects and the easy performance of intubation.

Study Type

INTERVENTIONAL

Purpose

TREATMENT

Conditions

Intubation

Interventions

Low dose midazolamDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who need rapid sequence intubation in emergency room Exclusion Criteria: * in hypotension(systolic blood pressure less than 90 mmHg * severe trauma patients * pregnant * allergic to midazolam, etomidate

Locations (2)

Seoul National University Bundang Hospital, Emergency room

Seongnam-si, Gyeonggi-do, South Korea

Boramae Medical Center

Seoul, South Korea

Data from ClinicalTrials.gov

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