A Study on Intima Media Thickness (IMT) in Middle-aged Subjects

AstraZeneca200 enrolled

Overview

This is an observational study to measure the thickness of artery walls in the neck (intima media thickness IMT) by ultrasound examination in middle-aged subjects with central obesity. The purpose of this study is to obtain local data how common asymptomatic atherosclerosis is, and to investigate the association between Cardiovascular Disease risk factors and intima media thickness (IMT) in the Hong Kong population. Results from this study may enhance the public awareness of asymptomatic atherosclerosis and understand its role in the development of Cardiovascular Disease in Hong Kong.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Atherosclerosis

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female aged 55 years or above. * Waist circumference: male more than 90 cm; female more than 80 cm. Exclusion Criteria: * Any known chronic diseases requiring long-term medication such as hypertension, diabetes and hyperlipidemia. * Presence of known cardiovascular diseases including cerebro-vascular disease, coronary heart disease and peripheral artery disease. * Presence of any active major diseases that may interfere the physical conditions and body weight of subjects during the study period, which include malignancy, infection, renal or liver function impairment, recent major surgery (within 3 months).

Locations (1)

Research Site

Hong Kong, Hong Kong

Outcomes

Primary Outcomes

To investigate the prevalence of asymptomatic atherosclerosis by measurement of intima media thickness (IMT) in middle-aged subjects with central obesity in Hong Kong,

Time frame: during the one single study visit

Secondary Outcomes

To examine the association between IMT value and cardiovascular disease (CVD) risk factors, and blood lipid and glucose profiles in middle-aged centrally obese subjects in Hong Kong.

Time frame: During the one single study visit

IMT results to be compared with what being reported in the recent literature on normal Chinese population.

Time frame: During the one single study visit

Data from ClinicalTrials.gov

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