Islet After Kidney Transplant for Type 1 Diabetes

Inclusion Criteria: * Patients with type 1 diabetes mellitus, who have a stable functioning renal transplant, are taking the appropriate maintenance immunosuppression and have no severe health problems that preclude them receiving an islet transplant will be considered for inclusion. Exclusion Criteria: * Have a history of or findings suggestive of unstable diabetic complications (e.g. active eye disease) * Active infections (clinically or by laboratory testing) * History of current malignancy or suspicion of malignancy until properly investigated and excluded * Liver or biliary abnormalities * Unstable cardiovascular disease * Findings to suggest immunological sensitization or those women who have the potential to get pregnant and are not using a sufficient method of contraception