Milk Components and Metabolic Syndrome

University of Copenhagen193 enrolled

Overview

Milk contains a vast number of bioactive components that have been suggested to have a positive impact on human health, of special interest is the effects related to metabolic syndrome and obesity but the effect of the individual milk components is not clear. This study examine whether it is beneficial for overweight and obese children to increase the intake of skim milk, or whey or casein in relation to bodyweight and markers of MS. The participants will be randomized to receive skim milk, whey milk drink, casein milk drink or mineral water for 3 mo. They will be examined at baseline, end of intervention and followed up 3 month later.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

193

Conditions

Obesity Metabolic Syndrome

Interventions

Eligibility

Sex: ALLMin age: 12 YearsMax age: 15 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 12 years to 15 years old * iso BMI larger than 25 * habitual milk intake less than 250 ml/day * non-smoker * healthy at the time of inclusion Exclusion Criteria: * chronic illnesses * intake of antibiotic 1 mo before start of intervention

Outcomes

Primary Outcomes

body composition and markers for metabolic syndrome (e.g.fasting insulin, glucose, lipid profile, CRP, PAI-1, tPA)

Time frame: at baseline, after intervention and body composition 3 mo after end of intervention

Secondary Outcomes

diet

Time frame: baseline and end of intervention

pulse wave velocity,

Time frame: baseline and end of intervention

blood pressure, metabolomics, IFG-I, IGFBP-3, appetite regulatory hormones,immune parameters, bone turn over parameters, composition of microbiota, vitamin D, physical activity

Time frame: baseline and end of intervention

Milk Components and Metabolic Syndrome

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes