Effect of Chronic Supplementation of L-arginine in the Muscular Performance

Phase 4TerminatedNCT00785811

Sanofi36 enrolled

Overview

The primary purpose of this study is to evaluate the effect of oral administration of L-arginine in the muscular fatigue of the quadriceps, expressed in terms of the Fatigue Resistance Factor (FRF). The secondary purpose of this study is to evaluate the effect of oral administration of L-arginine in the muscular force the quadriceps.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Muscular Fatigue

Interventions

L-arginine aspartate (Targifor)DRUG

3g of L-arginine taken orally in a single daily dose for 8 weeks

Placebo L-arginine aspartate (Targifor)DRUG

Placebo of L-arginine taken orally in a single daily dose for 8 weeks

Eligibility

Sex: ALLMin age: 20 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: Healthy young adults for both sex; Age between 20 and 55 years; Slight or moderate physical activity, 30 minutes per day, at least 3 times a week; Exclusion criteria: Cardiac or pulmonary disease; Previous history of knee surgery or skeletal muscular dysfunctions in hip, knee or ankle joints; Athletic person (intensive anaerobic activity); None practiced of physical activity regularly; Medications usage The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Locations (1)

Sanofi-Aventis Administrative Office

São Paulo, Brazil

Outcomes

Primary Outcomes

Fatigue Resistance Factor (FRF)

Time frame: Throughout the study

Secondary Outcomes

Maximum force in Newton (N) and fast or explosive force

Time frame: at time 30% of the maximum isometric force

Maximum force in Newton (N) and fast or explosive force

Time frame: at time 50% of the maximum isometric force

Maximum force in Newton (N) and fast or explosive force

Time frame: at time 90% of the maximum isometric force

Data from ClinicalTrials.gov

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