Ziprasidone vs Standard Therapy for Agitated Patients in the ED

George Washington University

Overview

The primary objective is to determine if ziprasidone is superior to standard therapies in the emergency department treatment of the acutely agitated patient. The primary outcome will be the length of time taken until the patient is ready to be evaluated by the psychiatric service, or until a disposition is made.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Conditions

Psychosis Agitation Delirium

Interventions

ziprasidoneDRUG

ziprasidone 20mg IM

Standard therapyDRUG

Haldol 5mg/ Ativan 2mg IM

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Acutely agitated * Requires chemical sedation Exclusion Criteria: * Physician preference for a specific chemical sedative * Known allergy to any study medications

Locations (1)

The George Washington University Medical Center, Dept of Emergency Medicine

Washington D.C., District of Columbia, United States

Outcomes

Primary Outcomes

length of time from triage until patient is either ready to be seen by psychiatry or is ready to have a disposition made

Time frame: During ED stay

Secondary Outcomes

Length of time taken to sedate patient

Time frame: Ed visit

Total time spent in restraints

Time frame: ED visit

Cost effectiveness of the therapy

Time frame: ED visit

Data from ClinicalTrials.gov

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