Study of IMC-1121B in Patients With Advanced Solid Tumors Not Responding To Standard Therapy

Inclusion Criteria: * Patients with histopathologically-documented, measurable or evaluable (non-measurable), advanced primary or recurrent solid tumors who have not responded to standard therapy or for whom no standard therapy is available * Eastern Cooperative Oncology Group (ECOG) performance status score of ≤2 at study entry. * Able to provide written informed consent. * A life expectancy of \>3 months. * Adequate hematologic function, as defined by: * an absolute neutrophil count ≥1500/mm3 * a hemoglobin level ≥10 gm/dL * a platelet count ≥100,000/mm3 * Adequate hepatic function, as defined by: * a total bilirubin level ≤1.5 x the upper limit of normal (ULN) * aspartate transaminase (AST) and alanine transaminase (ALT) levels ≤2.5 x the ULN or ≤5 x the ULN if known liver metastases * Adequate renal function, as defined by a serum creatinine level ≤1.5 x the ULN. * Use of effective contraception , if procreative potential exists. * Adequate recovery from recent surgery, chemotherapy, and radiation therapy. At least 28 days must have elapsed from major surgery, prior chemotherapy, prior treatment with an investigational agent or device, or prior radiation therapy * Accessible for treatment and follow-up. Patients enrolled in this trial must be treated at the participating center. Exclusion Criteria: * Patients with large centrally-located pulmonary lesions adjacent to or invading large blood vessels. * Patients who have had chemotherapy or therapeutic radiotherapy within 28 days (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or patients with ongoing side effects ≥ grade 2 due to agents administered more than 28 days earlier. * Prior left chest wall radiotherapy or a cumulative anthracycline dose ≥300 mg/m2 (if the ejection fraction is within normal institutional limits, the patient can be enrolled). * Any concurrent malignancy other than non-melanomatous skin cancer or carcinoma in situ of the cervix. Patients with a previous malignancy but without evidence of disease for ≥3 years will be allowed to enter the trial. * Uncontrolled intercurrent illness including, but not limited to: * ongoing or active infection requiring parenteral antibiotics * symptomatic congestive heart failure (class III or IV of the New York Heart Association classification for heart disease) * unstable angina pectoris, angioplasty, stenting, or myocardial infarction within 6 months * uncontrolled hypertension (systolic blood pressure ≥160 mm Hg, diastolic blood pressure \>100 mm Hg, found on two consecutive measurements separated by a 1-week period despite adequate medical support) * clinically significant cardiac arrhythmia (multifocal premature ventricular contractions, bigeminy, trigeminy, ventricular tachycardia that is symptomatic or requires treatment or asymptomatic sustained ventricular tachycardia) * uncontrolled diabetes * psychiatric illness/social situations that would compromise patient safety or limit compliance with study requirements * patients with symptomatic brain metastases (patients with a history of brain metastases must have received definitive surgery or radiotherapy, be clinically stable, and not taking steroids; anticonvulsants are allowed) * A serious or nonhealing active wound, ulcer, or bone fracture. * Known human immunodeficiency-positivity. * A major surgical procedure, an open biopsy, or a significant traumatic injury within 28 days prior to treatment. * Current or recent use (within 28 days) of a thrombolytic agent. * Current or recent use (within 28 days) of full-dose warfarin (an exception is low-dose warfarin to maintain patency of preexisting, permanent, indwelling intravenous (i.v.) catheters; for patients receiving warfarin, the international normalized ratio \[INR\] should be \<1.5). Patients requiring heparin are excluded. * Chronic daily treatment with aspirin (\>325 mg/day) or nonsteroidal anti-inflammatory medications known to inhibit platelet function (cyclooxygenase-2 \[COX-2\] inhibitors are permitted). * A history or clinical evidence of a deep venous or arterial thrombosis (including pulmonary embolism) within the last 6 months prior to study entry. * Proteinuria ≥1+ by routine urinalysis (patients with a protein value of ≤500 mg confirmed by a 24-hour urine collection are eligible). * Pregnant (confirmed by serum beta human chorionic gonadotropin \[βHCG\]) or breast feeding. * Prior treatment with bevacizumab or other agents specifically targeting VEGF ligand or receptor within 6 weeks of study entry. * Monoclonal antibodies within 6 weeks of study entry. * Positive anti-IMC-1121B antibody response. * A history of allergic reactions to monoclonal antibodies or other therapeutic proteins. * The subject is the investigator, sub-investigator, or anyone directly involved in the conduct of the protocol.