Diaphragmatic Function in Ventilated Patients

University Hospital, Montpellier55 enrolled

Overview

Animal studies showed that controlled mechanical ventilation (CMV) can induce dysfunction of the diaphragm, resulting in an early-onset and progressive decrease in diaphragmatic force-generating capacity, called ventilator-induced diaphragmatic dysfunction (VIDD).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Critically Ill

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Invasive mechanical ventilation (tracheally intubated or tracheotomized) less than 48h.· * Duration of mechanical ventilation for at least 72h.· * Subject itself or its next of kin has given written informed consent Exclusion Criteria: * Patient is less than 18 years or more than 85 years of age· * The attending physician refuses to allow enrollment· * The patient refuses informed consent * Next of kin is unavailable or refuses informed consent· * Pregnant or breast-feeding female. * A pregnancy test will be performed in all female patients less than 60 years of age.· * Any contraindication to use cervical magnetic stimulation (mechanical cardiac assist device …).· * Presence or suspicion of prior diaphragm injury or chronic disease· * Presence or suspicion of a central nervous system (CNS) disorder, including (but not limited to): CNS infarction, bleeding, tumor, or infection

Locations (2)

Department of Anesthesia and Critical Care (DAR B)

Saint-Eloi University Hospital of Montpellier, Montpellier, France

Service de Pneumologie et Réanimation

Groupe Hospitalier La Pitié-Salpêtrière-Paris, Paris, France

Outcomes

Primary Outcomes

Respiratory function parameters

Time frame: 6 weeks

Data from ClinicalTrials.gov

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