Magnetic Resonance Imaging-Guided Laser Induced Thermal Therapy for Treatment of Metastatic Brain Tumors

Inclusion Criteria: * Patient or family able and willing to give informed consent. * Subjects with metastatic cancer to the brain who have failed at least one conventional therapy (surgery, stereotactic radiosurgery, and/or whole brain radiotherapy). * Three or fewer previously treated or untreated lesion(s) in the brain. * Tumor size ≤ 3.0 cm in largest diameter. * MR imaging is not contraindicated for the patient. * Lesion(s) are clearly defined on pre-therapy contrast enhanced MRI scans as determined by the treating surgeon. * Able and willing to attend all study visits. * Karnofsky Performance Scale score \>70 for patients over the age of 15. * Lansky Play Scale \>70 for patients 15 years of age or younger. Exclusion Criteria: * Patients or family unwilling or unable to give written consent. * Patients who cannot physically fit in, or are too heavy for, the MRI scanner. * Patients with contra-indications to MRI imaging, such as, but not limited to, pacemakers or defibrillators, non-compatible aneurysm clips, shrapnel, or other internal ferromagnetic objects. * Known sensitivity to gadolinium-DTPA. * Based on Treatment Planning Imaging (MR and/or CT): * Brain edema and/or mass effect that causes midline shift or shift in wall of ventricle of more than 5 mm. * Lesions localized in the brain stem. * Lesions less than 5mm from primary branches of cerebral vessels, venous sinus, hypophysis or cranial nerves. * Evidence of recent (\<2 weeks) hemorrhage. * Presence of more than 3 brain tumors at the time of enrollment. * Symptoms and signs of increased intracranial pressure. * Medical issues which prohibit the patient from undergoing surgery (as determined by the treating surgeon, anesthesiologist, IMPAC clinic, referring physician). * Patients who are unable to receive corticosteroids. * Positive pregnancy test for women of child-bearing age.