This drug-drug interaction study is being conducted to evaluate the potential effect of Dimebon on the pharmacokinetics on dextromethorphan, a probe substrate of the cytochrome P450 2D6 (CYP2D6) enzyme, after multiple dose administration to healthy adult subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
14
Dextromethorphan HCl 30 syrup single dose
Dimebon 20 mg tablets given three times daily for 14 days plus Dextromethorphan HCl 30 syrup single dose administered on Day 12
Pfizer Investigational Site
New Haven, Connecticut, United States
Dextromethorphan exposure in combination with Dimebon 20 mg TID relative to Dextromethorphan exposure alone
Time frame: Day 12
Safety and Tolerability (Adverse Events, Vital Signs, Clinical Labs, Electrocardiograms)
Time frame: Day 15
Dextrorphan (the metabolite of dextromethorphan) exposure
Time frame: Day 12
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