A Multi-Center Randomised Controlled Study to Evaluate Laparoscopic Versus Open Surgery for Colorectal Cancer

Inclusion Criteria: * Informed consent * Pathologically confirmed adenocarcinoma * Pre-surgery image staging as (CT/MRI):T2-3,N0-2,M0,(TNM stage，AJCC，version of 2003) * Single tumor locating at cecum, ascending colon, descending colon, sigmoid colon, rectosigmoid junction, rectum(distance from anal verge more than 7cm) * Tumor diameter less than 6cm * Age 18-75 year * ECOG 0-2 * Predicted survival longer than 6 months * Normal liver, renal, bone marrow function: (GPT less than 2 ULN，total bilirubin less than 1.5mg/dl，Cr less than 1.5 ULN，WBC more than 4×109/L，PLT more than 100×109/L) * No previous history of gastrointestinal surgery * No previous history of chemotherapy or radiotherapy Exclusion criteria * Severe and uncontrolled medical disease including unstable angina pectoris, cardiac infarction and cerebral attack in 6 months * Could not tolerant general anesthesia or surgery for other organ dis-function * Allergy to chemotherapeutical agents in the protocol * History of other malignant tumor within 5 years * Severe mental disorder * Continued systematic steroid therapy * Woman during pregnancy or lactation * Under study of other clinical trial * No compliance of the protocol * Discovery of distant metastasis during surgery * Postsurgery stage of I or IV tumors