A Trial l of Panobinostat Given in Combination With Trastuzumab and Paclitaxel in Adult Female Patients With HER2 Positive Metastatic Breast Cancer

Inclusion Criteria: * Age \> 18 year old * Confirmed HER2+ metastatic breast cancer * Prior treatment and progression on trastuzumab * Patients must have adequate organ functions * Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1 Exclusion Criteria: * Patients who have had surgery within last 2 weeks prior to starting the treatment * Patients who receive concurrent therapy for brain metastases * Impaired heart function or clinically significant heart disease * Ongoing diarrhea * Liver or renal disease with impaired hepatic or renal functions * Concomitant use of any anti-cancer therapy or certain drugs * Female patients who are pregnant or breast feeding * Patients not willing to use an effective method of birth control Other protocol-defined inclusion/exclusion criteria may apply