Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams

Chulalongkorn University63 enrolled

Overview

This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicillin testing kit.

The results of skin test with immediate reading will be compared between alkali-treated penicillin G and DAP reagents from Diater

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Penicillin Allergy

Interventions

Immediate skin testPROCEDURE

Intradermal test with immediate reading

Eligibility

Sex: ALLMin age: 15 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with history of hypersensitivity reactions to betalactams; penicillin, aminopenicillins, and cephalosporins 2. 15-65 years of age Exclusion Criteria: 1. On antihistamine/ cannot discontinue antihistamine before the test 2. Having asthma exacerbation 3. Being pregnant 4. Suffering from severe systemic disease/ in bad health

Locations (1)

Faculty of Medicine, Chulalongkorn University

Bangkok, Thailand

Outcomes

Primary Outcomes

The skin testing results of in-house penicillin skin test and Penicillin G Sodium compared to commercial penicillin testing kit

Time frame: 1 year

Secondary Outcomes

Clinical correlation and side effects

Time frame: 1 year

Correlations between Penicillin skin test result with specific IgE and/or basophil activation test

Time frame: 1 year

Data from ClinicalTrials.gov

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