This study will evaluate methodologies for measuring pedal edema associated with calcium channel blockers in middle-aged and elderly subjects and patients with hypertension.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Enrollment
47
Two 5 mg tablets amlodipine daily for 6 weeks.
Two 5 mg tablets placebo to amlodipine daily for 6 weeks
Change From Baseline in Segmental Bioimpedance Measurements at 10 Kilohertz (KHz) at Week 2
Segmental biomimpedance was measured using a multifrequency analyzer (ImpediMed SFB7). The device was used to measure impedance (measured in Ohms) of a small current traveling between leads placed at the ankle and knee. Least Squares Mean Difference from Baseline in impedance is the primary endpoint.
Time frame: Baseline and 2 weeks
Change From Baseline in Foot Volume by Water Displacement (Weight of Water Displaced) at Week 2
Least Squares Mean Difference from Baseline
Time frame: Baseline and 2 weeks
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