Painless Subconjunctival Antibiotic and Antifungal Injection in Corneal Ulcer Patients

Inclusion Criteria: * The corneal ulcer patients who are diagnosed by ophthalmologist and have 2 of 3 in these following features. 1. corneal epithelial defect with stromal infiltration 2. reaction in anterior chamber 3. positive for bacteria or fungus * The patients have to receive subconjunctival antibiotic injection twice at least. * The patients must be informed consent. Exclusion Criteria: * The patients who have history of allergy of local anesthetics, antibiotics or antifungal drugs. * The patients who administered NSAIDs or weak opioids within 24 hours prior to subconjunctival antibiotic/antifungal injection. * Unable to cooperate with the treatment. * Pregnant women