Effects of Humidity (During CPAP Treatment) on Mucociliary Clearance in Patients With Obstructive Sleep Apnea

Fisher and Paykel Healthcare4 enrolled

Overview

That the level of humidification delivered to patients during CPAP treatment will alter the subjects mucociliary clearance rate and related mucus properties.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Obstructive Sleep Apnea

Interventions

CPAP + ThermoSmart™ humidityDEVICE

an absolute humidity (AH) of 28 mg/l +/- 2mg/l

CPAP + Conventional humidityDEVICE

an absolute humidity (AH) of 18 mg/l +/- 2 mg/l

CPAP + No added humidityDEVICE

ambient humidity

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Moderate to severe obstructive sleep apnea - Apnea Hypopnea Index (AHI) \> 15 * 75% of events during the diagnostic study must be obstructive Exclusion Criteria: * Currently using CPAP treatment OR have used it in the past 4 weeks * Intolerance of CPAP and/or CPAP mask in the past or during the titration night * Mouth breather (unable to breath through mouth for the study period) * \< 18years old * Nasal CPAP intolerance determined in the PSG-CPAP titration study * Serious nasal issues * Acute upper airway disease * Smoker * COPD * Congestive heart failure * Neuromuscular disease * Stroke

Locations (1)

Faculty of Medicine: Pulmonology: University of Sao Paulo Hospital

São Paulo, Brazil

Outcomes

Primary Outcomes

mucociliary clearance.

Time frame: pre and post cpap treatment with varying levels of humidity

Data from ClinicalTrials.gov

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