The purpose of this study is to see whether the combination of a muscle relaxant and anti-inflammatory drug is more effective at relieving pain in patients with neck strains or whiplash than either of the two medications alone.
Muscle relaxants have been used extensively for neck and back pain since muscle spasm is thought to play a role in the cycle of pain and spasm. However, prior studies have conflicting results regarding their additive effect when given in addition to analgesics such as the NSAIDs. Because they have the potential to lead to adverse events their efficacy should be clearly demonstrated before their routine use.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
61
5 mg orally every 8 hours as needed
Ibuprofen 400 mg every 8 hours as needed
Ibuprofen 400 mg plus cyclobenzaprine 5 mg every 8 hours as needed
Stony Brook University
Stony Brook, New York, United States
Pain
Time frame: Daily for 1 week
Use of Rescue Medications
the number of patients taking additional rescue medications beyond the study meds
Time frame: 24 hours
Time to Resumption of Work
Time frame: 1 week
Resumption of Work or School
number of patients resuming regular activity the day following enrollment.
Time frame: next day
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