Early Diabetes Resolution After Weight Loss Surgery

Vanderbilt University Medical Center75 enrolled

Overview

The primary objective is to compare inflammatory, hormonal, and metabolic changes in the very short term after various bariatric surgical procedures (Roux-en Y Gastric Bypass, Vertical Sleeve Gastrectomy, and Adjustable Gastric Banding)and other abdominal surgeries, as well as to compare these changes to diet-induced changes in the same population.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obesity Diabetes

Interventions

Weight loss surgeryPROCEDURE

Weight loss surgery

Laparoscopic abdominal surgeriesPROCEDURE

laparoscopic abdominal surgeries

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for surgery groups: * BMI of 30 kg/m2 or higher * Ages 18-65 * History of impaired glucose tolerance or T2DM Inclusion Criteria for normal weight group: * BMI of 30 kg/m2 or lower * Ages 18-65 Exclusion Criteria: * Development of an intercurrent infection * Prior gastric, duodenal, proximal jejunal surgery or pancreas resection * Current use of thiazolidinediones * Current use of dipeptidyl peptidase-IV inhibitors (e.g., sitagliptin) or glucagon-like peptide-1 analogs (e.g., exenatide) * Any condition felt by the PI or co-investigators to interfere with ability to complete the study

Outcomes

Primary Outcomes

Determine to what extent improvements in glycemic control can be attributed to caloric restriction after weight loss surgery

Time frame: 10 days post-op

Secondary Outcomes

Determine changes in inflammatory markers after weight loss surgery

Time frame: 10 days post-op

Data from ClinicalTrials.gov

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