The purpose of this study for children with a new diagnosis of Crohn's disease is to identify biomarkers found in the blood or stool to help predict which children are at risk of developing complications.
It is estimated that between 15-20% of children with Crohn's disease will develop complications that can require surgery within the first three years of diagnosis. The purpose of this study for children with a new diagnosis of Crohn's disease is to identify biomarkers found in the blood or stool to help predict which children are at risk of developing complications. A total of 2000 children with newly-diagnosed Crohn's disease will be enrolled within 30 days of diagnosis. Up to 28 medical sites in the United States and Canada will participate in the study.
Study Type
OBSERVATIONAL
Enrollment
1,813
Identify demographic, clinical, microbial, genetic, and/or immunologic risk factors influencing the likelihood of rapid development of complicated disease phenotypes manifested as penetrating or stricturing disease and need for surgery.
Time frame: 3 years
Develop and validate risk stratification by stratifying patients into different levels of risk at diagnosis based on clinical, demographic, host microbial ecology, immune, and genetic determinants.
Time frame: 3 years
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Cedars-Sinai Medical Center
Los Angeles, California, United States
UCLA Medical Center
Los Angeles, California, United States
University of California at San Francisco
San Francisco, California, United States
Connecticut Children's Medical Center
Hartford, Connecticut, United States
Nemours Children's Clinic
Jacksonville, Florida, United States
Emory-Children's Center - Emory University School of Medicine
Atlanta, Georgia, United States
Children's Center for Digestive Healthcare
Atlanta, Georgia, United States
The University of Chicago
Chicago, Illinois, United States
Riley Children's Hospital - Indiana University School of Medicine
Indianapolis, Indiana, United States
Johns Hopkins Children's Center
Baltimore, Maryland, United States
...and 18 more locations