Although data on cardioprotective effects (as profile of troponin I)of perioperative maintenance of normothermia during CABGs are already known, little is known about the effects of maintaining normothermia on clinical outcomes of patients submitted to coronary surgery. Being acute renal failure (ARF) and atrial fibrillation (AF) the two most frequent complications of this surgery, this study compare as primary end point the rate of postoperative ARF and AF in two group of patients, one actively warmed with Thermowrap and the control group receiving standard institutional care.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
300
Thermowrap set at 37 °C before induction of anesthesia and maintained until initiation of CPB; during CPB set to "monitoring" and set again to 37 °C from rewarming during CPB to end of surgery.
Dept. of Anesthesia & ICU, IRCCS Centro Cardiologico Monzino
Milan, Italy
Rate of atrial fibrillation
Time frame: First 48 postoperative hours
Rate of acute renal failure
Time frame: First 48 postoperative hours
Rate of Myocardial infarction and low output syndrome
Time frame: First postoperative 48 hours
Rate of Type I neurological injury
Time frame: First 48 postoperative hours
Total units of RBCs transfused
Time frame: First 48 postoperative hours
Length of mechanical ventilation
Time frame: First 48 postoperative hours
Rate of in-hospital mortality
Time frame: 30 postoperative days
Intensive Care Unit length of stay
Time frame: 30 postoperative days
Hospital length of stay
Time frame: 30 postoperative days
Cardiac Troponin I (cTnI) curve
Time frame: First postoperative 24 hours
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