Multiple Rising Oral Dose Study of PG 760564 Administered Twice Daily to Healthy Male/Female Volunteers for 14 Days

Inclusion Criteria: * Healthy males and surgically sterile or post-menopausal (last menstrual period \> 1 year at the time of enrollment) healthy females, 18-45 years of age, inclusive, at screening; * Who have not used tobacco or nicotine-containing products within the past 3 months; * Willing to abstain from caffeine or xanthine-containing beverages, including coffee and tea, chocolate, alcohol, grapefruit juice, and Seville oranges, from 24 hours before admission and for the duration of the study; * Who have a body mass index (BMI) between 18 and 32 kg/m2. Exclusion Criteria: * History of diabetes, cardiovascular, hepatic, renal, or malabsorptive disease; * History of peptic ulcer disease, hemorrhoids, GI surgery (appendectomy and cholecystectomy are allowed), or GI bleeding; * History of autoimmune disease; * History of immunodeficiency or of unusual susceptibility to infectious diseases; * History of tuberculosis, acquired immunodeficiency syndrome (AIDS), or infection with human immunodeficiency virus (HIV); * Any history of hypersensitivity or clinically significant allergy to any drug; * Personal or family history of prolonged QT syndrome or any cardiac conduction abnormality; * Family history of sudden death; * History of uveitis or inflammatory ocular disease