Etodalac, Etoricoxib and Dexamethasone for Prevention of Pain ,Swelling and Trismus Following Third Molar Surgery

Tel-Aviv Sourasky Medical Center80 enrolled

Overview

The purpose of this study is to determine whether Etodalac, Etoricoxib and Dexamethasone are effective for Prevention of Pain ,Swelling and Trismus Following Third Molar Surgery

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Trismus Edema Pain

Interventions

Etodalac, Etoricoxib and DexamethasoneDRUG

Dexamethasone sodium phosphate 8 mg 1 hour before the extraction, 4 mg the day after the extraction and another 4 mg at second day to the extraction. Etoricoxib 120 mg 1 hour before the extraction, 120 mg the day after the extraction and another 120 mg at second day to the extraction. Etodalac 600 mg 1 hour before the extraction, 600 mg the day after the extraction and another 600 mg at second day to the extraction.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who are refered for third molar extraction to our center * Must be able to swallow tablets Exclusion Criteria: * Diabetes mellitus * Thyroid diseases * Cardiovascular diseases * renal diseases * hepatic diseases * respiratory system diseases * adrenal diseases * Allergy to Etodalac, Etoricoxib or Dexamethasone * Gastric ulcers * psychiatric diseases * Pregnant or breast feeding womans

Outcomes

Primary Outcomes

PAIN- By VAS graded from 1-10 TRISMUS- By MAX mouth opening from the first incisors adages POST OPERATIVE SWELLing - By measurement the distance between the Right and LEFT ear's tragus

Time frame: 1 week

Data from ClinicalTrials.gov

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