Effects of Contrast Media on Subjects With Stable Reduced Renal Function Undergoing Contrast-Enhanced Computed Tomography

Inclusion Criteria: * Males and females 18 years of age or older * Subjects scheduled for a clinically indicated CECT requiring 40 grams of iodine (125 mL) * Subjects have an abnormal screening SCr that results in a calculated eGFR of \< 60 mL/min/1.73 m2 using the MDRD formula and acute causes for an elevation in SCr have been excluded * Subjects have stable reduced renal function which is defined as an abnormal screening SCr measurement with a \< 15% difference from the oldest historical SCr measurement obtained within the proceeding 1 week to 12 weeks * Subjects must provide written consent and agree to abide by the site and study requirements Exclusion Criteria: * Subjects previously entered into this study * Subjects on dialysis * Subjects received any investigational drug within 30 days of contrast administration or participated in an investigational study within 30 days prior to study enrollment * Subjects have undergone a procedure using iodinated or gadolinium contrast agent within 7 days prior to contrast administration, or is scheduled to receive additional doses of contrast agents during the 48-72 hour post-study contrast administration * Subjects in acute renal failure or have one or more known causes of acute renal failure * Subjects have known or suspected unstable renal function * Subjects scheduled for a surgical intervention or other procedure within 72 hours after the contrast administration * Subjects taking NSAIDs (with the exception of ASA) and/or any type of diuretics who cannot discontinue these drugs post contrast administration and hold all subsequent doses until the 48-72 hour post contrast SCr has been drawn * Subjects taking aminoglycosides * Subjects known to have an organ transplantation * Subjects have severe congestive heart failure (Class III-IV)