Terlipressin Administration in Septic Shock Refractory to Catecholamines

Assaf-Harofeh Medical Center30 enrolled

Overview

terlipressin is given to refractory septic shock patients who do not respond to noradrenalin in Israel and Europe. It is given by bolus injection. we attempt to investigate weather it is better to give it by continuous drip and avoid abrupt changes in BP and heart function

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Septic Shock

Interventions

terlipressinDRUG

1 mg of terlipressin one time only

terlipressinDRUG

1 mg of terlipressin in 50 cc of NS given at a drip of a total of 6 h

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * septic shock patients receiving above 0.5 mcg/kg NA Exclusion Criteria: * allergy to terlipressin, CHF, IHD, pregnancy

Locations (1)

Asaf Harofeh MC

Zrifin, Israel

Outcomes

Primary Outcomes

CI, SVR,HR,BP, noradrenalin administration,renal function

Time frame: 6 mo

Central Contacts

Tal Mann, Dr

CONTACT

97257345789 tal_mb@hotmail.com

Data from ClinicalTrials.gov

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