Decompressive laparotomy with temporary abdominal closure, will decrease of overall mortality and major morbidity in patients with abdominal compartment syndrome during acute pancreatitis in comparison with percutaneous puncture with placement of abdominal catheter.
We anticipated that decompressive laparotomy with temporary abdominal closure, beside all potentially negative side effects that early open surgery carries in patients with acute pancreatitis, results in decrease of overall mortality and major morbidity. The DECOMPRESS study is designed to compare effects of decompressive laparotomy with temporary abdominal closure and percutaneous puncture with placement of abdominal catheter in patients with abdominal compartment syndrome during acute pancreatitis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Surgical intervention including midline incision with temporary abdominal closure and several planed staged relaparotomies
Installation of abdominal catheter percutaneously via abdominal centesis 2cm bellow the umbilicus
Clinic for Emergency Surgery, Clinical Center of Serbia and School of Medicine, University of Belgrade
Belgrade, Serbia
RECRUITINGSurgical Department, Clinical Center "Bezanijska Kosa" and School of Medicine, University of Belgrade
Belgrade, Serbia
RECRUITINGSurgical Department, Clinical Center "Zvezdara" and School of Medicine, University of Belgrade
Mortality rate during the hospital stay for patients with abdominal compartment syndrome during acute pancreatitis.
Time frame: 2 years
duration time of organ failure
Time frame: 2 years
development of a new organ failure
Time frame: 2 years
number of infectious complications,
Time frame: 2 years
needs for necrosectomy,
Time frame: 2 years
intensive care stay
Time frame: 2 years
total hospital stay
Time frame: 2 years
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Belgrade, Serbia
Surgical Department, Military-Medical Academy
Belgrade, Serbia
RECRUITINGSurgical Department, Clinical Center "Dr Dragisa Misovic," and School of Medicine, University of Belgrade,
Belgrade, Serbia
RECRUITING