Multi-national Cirrhosis Study to Characterise the Association Between the Pharmacokinetics of NRL972 and Disease Severity.

Inclusion Criteria: Subjects meeting the following conditions will be eligible for enrolment: * Patient has given his or her written informed consent to the study participation, prior to study specific procedures * Male and female (non-child-bearing potential = post-menopausal or medically adequate contraception) * Ethnicity: any * Age: 18 to 80 years of age * Patients with histologically established diagnosis of hepatic cirrhosis and available histological material for review by the central histopathologist or a CTP score greater than or equal to 10 points plus an objective imaging study (CT or NMR scan) within 3 months of the screening visit with a confirmation of hepatic cirrhosis (scans are collected and reviewed), but excluding patients with the diagnosis of primary biliary cirrhosis, primary sclerosing cholangitis and cystic fibrosis-associated liver disease * Present CTP-class A, B or C * Medically fit to undergo the protocol-defined procedures without undue risk and discomfort * Predicted life-expectancy greater than or equal to 6 months by clinical judgement Exclusion Criteria: Subjects of any of the following categories will be excluded from enrolment: * Previous participation in this trial (except for scheduled re-testing in relation to technical difficulties with initial test) * Participant in any other trial during the last 90 days * Donation of blood during the last 60 days or a history of blood loss exceeding 300 mL within the last 3 months * Any donation of germ cells, blood, organs, or bone marrow during the course of the study * History of any clinically relevant allergy (including hypersensitivity to the trial medications) * Presence of clinical relevant acute or chronic infection (other than chronic viral hepatitis, if applicable) * Use of confounding concomitant medication * Presence or history of any end-stage (co-)morbidity (excluding the effects of hepatic cirrhosis) such as: malignancy and clinically relevant systemic diseases * Suspicion or evidence that the subject is not trustworthy and reliable * Suspicion or evidence that the subject is not able to make a free consent or to understand the information in this regard * Primary biliary cirrhosis and primary sclerosing cholangitis * Cystic fibrosis * Previous liver transplantation or intended liver transplantation within 6 months after enrolment * Patients having undergone previous transjugular intrahepatic portosystemic shunt (TIPS) or portocaval anastomosis (PCA) * Patients who are employees at the investigational site, relatives or spouses of the investigator * Current drug, or medication abuse Special restrictions for female patients: * Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation. * Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, including women whose career, lifestyle, or sexual orientation precludes intercourse with a male partner and women whose partners have been sterilized by vasectomy or other means, unless they meet the following definition of post-menopausal: 12 months of natural (spontaneous) amenorrhea or 6 months of spontaneous amenorrhea with serum FSH levels greater than 40 mIU/m or 6 weeks post surgical bilateral oophorectomy with or without hysterectomy or hysterectomy or are using one or more of the following acceptable methods of contraception: surgical sterilization (e.g., bilateral tubal ligation, vasectomy), hormonal contraception (implantable, patch, oral), and double-barrier methods (any double combination of: IUD, male or female condom with spermicidal gel, diaphragm, sponge, cervical cap)