Relation of Circulating Endothelium-derived Microparticle to Carotid Atherosclerosis

Kurume University154 enrolled

Overview

The investigators hypothesized that circulating endothelium-derived microparticle (EMP) may be a useful surrogate marker of atherosclerosis and future episode of cerebrovascular events. Peripheral blood is drawn at the time of carotid ultrasound examination. Circulating EMPs are counted using flow-cytometry. The correlation among circulating EMP, ultrasound findings, and atherosclerotic risk factors are determined by multiple stepwise regression analysis. The prevalence of cerebrovascular events is also determined during 3-year follow-up period.

Study Type

OBSERVATIONAL

Enrollment

154

Conditions

Atherosclerosis

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who undergo carotid ultrasound examination for screening of atherosclerosis Exclusion Criteria: * Cerebrovascular events within the last 12 months * Acute coronary syndrome, coronary and peripheral intervention within the last 6 months * Uncontrolled heart failure * Other severe systemic diseases

Locations (1)

Kurume University Hospital

Kurume, Fukuoka, Japan

Outcomes

Primary Outcomes

The number of circulating EMPs

Time frame: at the time of carotid ultrasound examination

Secondary Outcomes

The occurrence of cerebrovascular and/or cardiovascular events

Time frame: 3 years

Data from ClinicalTrials.gov

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